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- Title
Farnesol as a Quorum-sensing Molecule in Candida albicans.
- Authors
Cho, Tamaki; Aoyama, Toshihiro; Toyoda, Mika; Nakayama, Hironobu; Chibana, Hiroji; Kaminishi, Hidenori; Calderone, Richard A.
- Abstract
Farnesol is one of the quorum sensing molecules of Candida albicans. In this report, we discuss the effects of farnesol on: 1. growth of Candida albicans in vitro and in vivo; 2. the incorporation of biomolecules into the cell wall of Candida albicans; and 3. cytokine expression by the immune system. Our results indicate genes of Candida albicans expressed at an early stage of quorum-sensing. Half of these genes are known and two-thirds of known genes are up-regulated by two types of transcription factors.
- Subjects
QUORUM sensing; IMMUNE system; CANDIDA albicans; TRANSCRIPTION factors; BIOMOLECULES
- Publication
Japanese Journal of Medical Mycology, 2008, Vol 49, Issue 4, p281
- ISSN
0916-4804
- Publication type
Article
- DOI
10.3314/jjmm.49.281