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- Title
Fluvoxamine treatment for chronic PTSD: a pilot study.
- Authors
De Boer, Marc; Op den Velde, Wybrand; Falger, Paul J.R.; Hovens, Johannes E.; De Groen, Johannes H.M.; Van Duijn, Hans; De Boer, M; Op den Velde, W; Falger, P J; Hovens, J E; De Groen, J H; Van Duijn, H
- Abstract
A group of 24 Dutch World War II Resistance veterans with a documented traumatic war history and a (partially) positive diagnosis of current posttraumatic stress disorder (PTSD) was studied. This special group of war victims is characterised by chronicity, suffering from intractable posttraumatic complaints for decades. They were treated with fluvoxamine (Fevarin), a selective serotonin reuptake inhibitor with antidepressive and anxiolytic properties. The study was designed as an open-ended, outpatient pilot study, with a treatment period of 12 weeks. Results of clinical examination, and questionnaires investigating PTSD, depression, sleeping problems, anxiety, and vital exhaustion indicate that a significant number of the subjects improved with respect to their PTSD symptomatology, and their symptoms of anxiety and vital exhaustion. However, at the end of the study, quantitative improvement was modest. The results indicate that treatment with fluvoxamine may offer alleviation of chronic PTSD symptoms, in particular insomnia, nightmares, anxiety, intrusive recollections, guilt feelings and tiredness.
- Subjects
NETHERLANDS; AMINES; COMPARATIVE studies; DRUG administration; DOSE-effect relationship in pharmacology; RESEARCH methodology; MEDICAL cooperation; POST-traumatic stress disorder; RESEARCH; PSYCHOLOGY of veterans; PILOT projects; EVALUATION research
- Publication
Psychotherapy & Psychosomatics, 1992, Vol 57, Issue 4, p158
- ISSN
0033-3190
- Publication type
journal article
- DOI
10.1159/000288593