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- Title
DNA DAMAGE AND REPAIR IN LIGHT-SENSITIVE HUMAN SKIN DISEASE.
- Authors
Cleaver, Ph.D., J. E.
- Abstract
The article presents details on DNA damage and repair in light-sensitive human skin diseases. The skin can become extremely sensitive to sunlight for varied reasons: a loss in the normal protection afforded by melanin; the presence of light sensitizing compounds in the skin; allergic reactions, either idiopathic or induced by photosensitizers; a decreased tolerance of individual cells in the skin to light. In the first three categories the amount of direct sunlight is increased. In the latter the initial amount of direct damage is not increased, but the ability of cells to withstand damage has decreased.
- Subjects
DNA damage; DNA repair; MOLECULAR genetics; SKIN diseases; PHOTOSENSITIZERS; SUNSHINE
- Publication
Journal of Investigative Dermatology, 1970, Vol 54, Issue 3, p181
- ISSN
0022-202X
- Publication type
Article
- DOI
10.1111/1523-1747.ep12280225