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- Title
The lactose system in Klebsiella aerogenes V9A: 3. Specific repression of the lac operon by melibiose and raffinose.
- Authors
Reeve, E. C. R.
- Abstract
In Klebsiella aerogenes strain V9A melibiose and raffinose fail to induce the lac operon and strongly repress its induction by isopropyl-β-d-thiogalactopyranoside (IPTG). This repression is specific to the lac system and is not released by cAMP, which releases the catabolite repression exerted by glucose and sucrose. It is concluded that melibiose and raffinose bind to the lac repressor molecule in Klebsiella V9A, competitively displacing IPTG, and that the resulting complex is able to repress the lac operon. Other Klebsiella strains tested show the same repression phenomenon.
- Publication
Genetics Research, 1973, Vol 22, Issue 2, p217
- ISSN
0016-6723
- Publication type
Article
- DOI
10.1017/S0016672300013021