We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Synthesis, Structural Characterization, and Evaluation of the Biological Properties of Heteroleptic Palladium(II) Complexes.
- Authors
Khan, Hizbullah; Daraz, Nek; Khan, Muhammad Nasim; Said, Muhammad; Akhtar, Nosheen; Badshah, Amin; Khan, Amir Sada; Ali, Murad
- Abstract
Five heteroleptic palladium(II) complexes of the general formula Pd(PR3)(tu)Cl2, where PR3 = triphenylphosphine (1), diphenyl-otolylphosphine (2), diphenyl-p-tolylphosphine (3), diphenyl-t-butylphosphine (4), and diphenyl-o-methoxyphenylphosphine (5), and tu = 1,3-bis(2-methoxyphenyl) thiourea. They all have been synthesized and characterized by various spectroscopic techniques (elemental analysis, FTIR, and ¹H NMR and the ligand 1,3-bis(2-methoxyphenyl) thiourea was synthesized by single crystal X-ray diffraction technique). The synthesized compounds were screened for their antibacterial activity against four strains of bacteria (Escherichia coli, Shigella flexneri, Staphylococcus aureus, and Bacillus subtilis). The antitumor potential was evaluated in terms of activity against brine shrimp eggs and DNA interaction. The mixed ligand complexes have exhibited moderate antibacterial activity and promising antitumor potential.
- Subjects
HETEROLEPTIC compounds; PALLADIUM; X-ray diffraction; PHOSPHINE; BACILLUS subtilis
- Publication
Bioinorganic Chemistry & Applications, 2014, p1
- ISSN
1565-3633
- Publication type
Article
- DOI
10.1155/2014/916361