We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Free light chains: potential biomarker and predictor of mortality in alpha-1-antitrypsin deficiency and usual COPD.
- Authors
Hampson, Judith A.; Stockley, Robert A.; Turner, Alice M.
- Abstract
<bold>Background: </bold>Circulating free light chains (FLCs) can alter neutrophil migration, apoptosis and activation and may be a biomarker of autoimmune disease and adaptive immune system activation. These pathogenic roles could be relevant to lung disease in alpha 1 antitrypsin deficiency (A1ATD) and chronic obstructive pulmonary disease (COPD).<bold>Methods: </bold>Total combined (c)FLCs were measured using the FreeLite® assay in 547 patients with A1ATD and 327 patients with usual COPD in the stable state, and assessed for association with clinical phenotype, disease severity, airway bacterial colonisation and mortality. Univariate and multivariate analyses were undertaken.<bold>Results: </bold>Circulating cFLCs were static in the stable state when measured on 4 occasions in A1ATD and twice in usual COPD. Levels were inversely related to renal function (A1ATD and COPD p = <0.01), and higher in patients with chronic bronchitis (p = 0.019) and airway bacterial colonisation (p = 0.008). After adjusting for renal function and age the relationship between cFLCs and lung function was weak. Kaplan Meier curves showed that cFLC > normal (43.3 mg/L) significantly associated with mortality in both cohorts (A1ATD p = 0.001, COPD p = 0.013).<bold>Conclusions: </bold>cFLCs may be a promising biomarker for risk stratification in A1ATD and COPD.
- Subjects
UNITED Kingdom; ALPHA 1-antitrypsin; OBSTRUCTIVE lung disease diagnosis; NEUTROPHILS; APOPTOSIS; IMMUNOGLOBULINS; ALPHA 1-antitrypsin deficiency; DEMOGRAPHY; OBSTRUCTIVE lung diseases; RESEARCH evaluation; RISK assessment; SURVIVAL analysis (Biometry); COMORBIDITY; DISEASE prevalence
- Publication
Respiratory Research, 2016, Vol 17, p1
- ISSN
1465-9921
- Publication type
journal article
- DOI
10.1186/s12931-016-0348-1