We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Studies Based on Preparation, Physical Characteristics, and Cellular Pharmacological Activities of Thin PLGA Film Loaded with Geniposide.
- Authors
Haiyan Zhang; Hao Liu; Nan Huang; Ya He; Tingting Lei; Xin Wang; Ming Yang; Guangming Luo
- Abstract
In this primary study, thin polylactic-co-glycolic acid (PLGA) film loaded with geniposide was first prepared and demonstrated on both physical and pharmacological aspects for its potential application on drug-eluting vascular stents. Physical parameters of geniposide-loaded thin film, such as crystal structure, molecular spectral characteristics, and release behavior in the whole process were detected. From X-Ray diffraction, the characteristic peak of crystal geniposide disappeared on geniposide-loaded PLGA film (GLPF) after it formed, which meant there was no agglomeration phenomenon, as geniposide was distributed in the form of single molecule. According to scanning electron microscopy (SEM) figure, the GLPF was more flat and uniform with better compactness. It inferred that release behavior of geniposide at the early stage (0~15 d) was in the form of free diffusion. Carrier PLGA began to degrade 15 days later, so the residual geniposide was also dissolved. Cellular pharmacological effects of geniposide on endothelial cells (ECs) and smooth muscle cells (SMCs) were also demonstrated on GLPF. 5% and 10% (w/w) geniposide-loaded PLGA (60 : 40) membrane indicated its significant effect on ECs promotion and SMCs inhibition. All provided feasible evidences for the development of new geniposide-coating vascular stent using PLGA as carrier.
- Subjects
CORONARY heart disease prevention; CORONARY restenosis prevention; ANALYSIS of variance; CELL culture; CONTROLLED release preparations; CRYSTALLIZATION; DIFFUSION; DRUG stability; DOSE-effect relationship in pharmacology; EPITHELIAL cells; HERBAL medicine; HIGH performance liquid chromatography; INFRARED spectroscopy; CHINESE medicine; POLYESTERS; PROBABILITY theory; REGRESSION analysis; RESEARCH; SCANNING electron microscopy; STATISTICAL hypothesis testing; T-test (Statistics); PHYTOCHEMICALS; DRUG-eluting stents; IN vitro studies; PHARMACODYNAMICS
- Publication
Evidence-based Complementary & Alternative Medicine (eCAM), 2014, Vol 2014, p1
- ISSN
1741-427X
- Publication type
Article
- DOI
10.1155/2014/352423