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- Title
A Bivalent Human Norovirus Vaccine Induces Homotypic and Heterotypic Neutralizing Antibodies.
- Authors
Atmar, Robert L; Ettayebi, Khalil; Ramani, Sasirekha; Neill, Frederick H; Lindesmith, Lisa; Baric, Ralph S; Brinkman, Amanda; Braun, Ralph; Sherwood, James; Estes, Mary K
- Abstract
A GII.2 outbreak in an efficacy study of a bivalent virus-like particle norovirus vaccine, TAK-214, in healthy US adults provided an opportunity to examine GII.4 homotypic vs GII.2 heterotypic responses to vaccination and infection. Three serologic assays—virus-like particle binding, histoblood group antigen blocking, and neutralizing—were performed for each genotype. Results were highly correlated within a genotype but not between genotypes. Although the vaccine provided protection from GII.2-associated disease, little GII.2-specific neutralization occurred after vaccination. Choice of antibody assay can affect assessments of human norovirus vaccine immunogenicity.
- Subjects
NOROVIRUSES; VACCINE immunogenicity; IMMUNOGLOBULINS; VIRUS-like particles; VACCINES
- Publication
Journal of Infectious Diseases, 2024, Vol 229, Issue 5, p1402
- ISSN
0022-1899
- Publication type
Article
- DOI
10.1093/infdis/jiad401