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- Title
Mutagenicity of comfrey (Symphytum Officinale) in rat liver.
- Authors
Mei, N.; Guo, L.; Fu, P. P.; Heflich, R. H.; Chen, T.
- Abstract
Comfrey is a rat liver toxin and carcinogen that has been used as a vegetable and herbal remedy by humans. In order to evaluate the mechanisms underlying its carcinogenicity, we examined the mutagenicity of comfrey in the transgenic Big Blue rat model. Our results indicate that comfrey is mutagenic in rat liver and the types of mutations induced by comfrey suggest that its tumorigenicity results from the genotoxicity of pyrrolizidine alkaloids in the plant.
- Subjects
COMFREY; LIVER; MUTAGENESIS; BORAGINACEAE; GENETIC mutation; RATS; IN vitro studies; RESEARCH; LIVER tumors; ANIMAL experimentation; ALKALOIDS; RESEARCH methodology; MUTAGENICITY testing; MEDICAL cooperation; EVALUATION research; COMPARATIVE studies; MUTAGENS; TRANSGENIC animals
- Publication
British Journal of Cancer, 2005, Vol 92, Issue 5, p873
- ISSN
0007-0920
- Publication type
journal article
- DOI
10.1038/sj.bjc.6602420