We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Variation rs9929218 and risk of the colorectal Cancer and adenomas: A meta-analysis.
- Authors
Wang, Huiyan; Gu, Dongying; Yu, Miao; Hu, Yanjun; Chen, Zhe; Huo, Xinying; Yu, Tao; Chen, Jinfei; Zheng, Yang
- Abstract
<bold>Backgrounds: </bold>Genome-wide association studies (GWAS) have identified multiple common CRC-related (colorectal cancer) SNPs (single nucleotide polymorphisms) including the Cadherin 1(CDH1) rs9929218 may act by increasing the risk of colorectal cancer, colorectal adenoma, or both. These studies, however, reported inconsistent associations.<bold>Methods: </bold>To derive a more accurate approximation of the connection, we carried out a meta-analysis of 12 published pieces of research including 11,590 controls and 8192 cases. We used odds ratios (ORs) and 95% confidence intervals (CIs) to evaluate the associations' strength.<bold>Results: </bold>Meta-analysis implied considerable association between CRC and rs9929218 (OR = 1.21, 95%CI 1.04-1.42 for GG versus AA; OR = 1.22, 95%CI 1.05-1.42 for GG/AG versus AA). In the subgroup analyses, significantly increased risks were found among Europeans.<bold>Conclusions: </bold>In summary, our meta-analysis studies in different populations confirmed that SNP rs9929218 is significantly associated with CRC risk and that this variant may have a greater impact on Europeans.
- Subjects
ADENOMATOUS polyps; ADENOMA; SINGLE nucleotide polymorphisms
- Publication
BMC Cancer, 2021, Vol 21, Issue 1, p1
- ISSN
1471-2407
- Publication type
journal article
- DOI
10.1186/s12885-021-07871-z