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- Title
Correlation between Drinking, Hepatocellular Carcinoma and Hepatitis B Surface Antigen.
- Authors
Shengxi, L.; Zhuge, S.; Hui, L.; Yinghui, G.
- Abstract
Objective: To describe the epidemiological characteristics of patients with hepatocellular carcinoma (HCC) to get more knowledge about the relationship between age, dietary habit, behavioural habit, living habit and HCC and clarify the risk of causing HCC by alcohol consumption. Methods: A case-control study was utilized. In the form of a questionnaire, 200 cases of HCC patients were investigated, and their related information was stored in a computer, the patients were divided into experimental and control groups. Meanwhile, the odds ratio (OR) and 95% confidence interval (95% CI) were estimated by using a logistic multiple regression method. Results: Using univariate analysis of variance to describe the basic characteristics of the two groups of patients, it showed that the factors closely related to the occurrence of HCC: hepatitis B surface antigen (HBsAg) positivity, liver cirrhosis, other chronic liver disease and schistosomiasis. But there was no obvious correlation between alcohol consumption and HCC. In addition, in the further analysis, no correlation between the number of drinking years, alcohol intake, and the drinking age was found. But HBsAg positivity and a history of chronic liver disease is closely associated with the occurrence of HCC; the HCC incidence of HBsAg-positive patients was significantly higher, In HBsAg-negative subjects, there was no significant correlation (p > 0.05) between alcohol consumption and the incidence of HCC. In the study of patients with chronic liver disease, the risk of causing liver cancer among alcohol drinking patients was higher than that among non-drinking patients. The risk was higher with higher alcohol consumption. Conclusion: Hepatitis B surface antigen positivity and chronic liver diseases are independent risk factors for HCC. Although drinking is not an independent risk factor, drinking would increase the possibility of causing HCC among patients with HBsAg positivity and a history of chronic liver disease and it would be especially noticeable with increased drinking consumption.
- Subjects
LIVER cancer patients; CANCER risk factors; LIVER cancer; ALCOHOL drinking; HEPATITIS associated antigen; CORRELATORS
- Publication
West Indian Medical Journal, 2016, Vol 65, Issue 4, p1
- ISSN
0043-3144
- Publication type
Article
- DOI
10.7727/wimj.2016.253