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- Title
Mouse Models for Studying Oral Cancer: Impact in the Era of Cancer Immunotherapy.
- Authors
Luo, J. J.; Young, C. D.; Zhou, H. M.; Wang, X. J.
- Abstract
Model systems for oral cancer research have progressed from tumor epithelial cell cultures to in vivo systems that mimic oral cancer genetics, pathological characteristics, and tumor-stroma interactions of oral cancer patients. In the era of cancer immunotherapy, it is imperative to use model systems to test oral cancer prevention and therapeutic interventions in the presence of an immune system and to discover mechanisms of stromal contributions to oral cancer carcinogenesis. Here, we review in vivo mouse model systems commonly used for studying oral cancer and discuss the impact these models are having in advancing basic mechanisms, chemoprevention, and therapeutic intervention of oral cancer while highlighting recent discoveries concerning the role of immune cells in oral cancer. Improvements to in vivo model systems that highly recapitulate human oral cancer hold the key to identifying features of oral cancer initiation, progression, and invasion as well as molecular and cellular targets for prevention, therapeutic response, and immunotherapy development.
- Subjects
LABORATORY mice; TREATMENT of oral cancer; ANIMAL models of cancer; EPITHELIAL cells; CANCER genetics; ORAL cancer patients; CANCER immunotherapy; ORAL cancer; PREVENTION; BIOLOGICAL models; RESEARCH; MOUTH tumors; ANIMAL experimentation; RESEARCH methodology; EVALUATION research; MEDICAL cooperation; COMPARATIVE studies; IMMUNOTHERAPY; MICE
- Publication
Journal of Dental Research, 2018, Vol 97, Issue 6, p683
- ISSN
0022-0345
- Publication type
journal article
- DOI
10.1177/0022034518767635