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- Title
Saw-tooth vertical saccades in progressive supranuclear palsy.
- Authors
Kim, Min-Ku; Lee, Dongje; Yang, Xu; Kim, Hyo-Jung; Choi, Jeong‑Yoon; Kim, Ji-Soo
- Abstract
These saccades were associated with alternating horizontal saccades, thus giving rise to a "saw-tooth" appearance, especially during downward saccades. According to a conductance-based model simulation, premature and poorly synchronized discharges from the degenerated IBNs cause breaks in the saccade trajectory and maladaptive superior colliculus activity, resulting in aberrant saccades that alter the intended trajectory of the ongoing saccades [[4]]. His fragmented vertical saccades were associated with alternating horizontal saccades, giving rise to a "saw-tooth" appearance, especially during downward saccades. The hypometric (stair-case pattern) vertical saccades were associated with alternating horizontal saccades, thus giving rise to a "saw-tooth" appearance, especially during downward saccades (Fig.
- Subjects
PROGRESSIVE supranuclear palsy; PARKINSONIAN disorders; RETICULAR formation; SUPERIOR colliculus; EXECUTIVE function; VESTIBULO-ocular reflex
- Publication
Journal of Neurology, 2023, Vol 270, Issue 7, p3644
- ISSN
0340-5354
- Publication type
Article
- DOI
10.1007/s00415-023-11696-0