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- Title
Quinic acid derivatives inhibit dengue virus replication in vitro.
- Authors
Zanello, Paula Rodrigues; Koishi, Andrea Cristine; de Oliveira Rezende Júnior, Celso; Oliveira, Larissa Albuquerque; Pereira, Adriane Antonia; de Almeida, Mauro Vieira; dos Santos, Claudia Nunes Duarte; Bordignon, Juliano
- Abstract
Background: Dengue is the most prevalent arboviral disease in tropical and sub-tropical areas of the world. The incidence of infection is estimated to be 390 million cases and 25,000 deaths per year. Despite these numbers, neither a specific treatment nor a preventive vaccine is available to protect people living in areas of high risk. Results: With the aim of seeking a treatment that can mitigate dengue infection, we demonstrated that the quinic acid derivatives known as compound 2 and compound 10 were effective against all four dengue virus serotypes and safe for use in a human hepatoma cell line (Huh7.5). Both compounds were non-virucidal to dengue virus particles and did not interfere with early steps of the dengue virus life cycle, including binding and internalization. Experiments using a replicon system demonstrated that compounds 2 and 10 impaired dengue virus replication in Huh7.5 cells. Additionally, the anti-dengue virus effects of the quinic acid derivatives were preserved in human peripheral blood mononuclear cells. Conclusions: Taken together, these data suggest that quinic acid derivatives represent a novel chemical class of active compounds that could be used to combat dengue virus infection.
- Subjects
DENGUE viruses; DENGUE; QUINIC acid; PUBLIC health; REPLICONS; VACCINATION
- Publication
Virology Journal, 2015, Vol 12, Issue 1, p1
- ISSN
1743-422X
- Publication type
Article
- DOI
10.1186/s12985-015-0443-9