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- Title
Peripheral Arterial Disease in Sub-Saharan Africa: A Review.
- Authors
Johnston, Lily E.; Stewart, Barclay T.; Yangni-Angate, Herve; Veller, Martin; Upchurch Jr., Gilbert R.; Gyedu, Adam; Kushner, Adam L.; Upchurch, Gilbert R Jr
- Abstract
<bold>Importance: </bold>Peripheral arterial disease (PAD) causes significant morbidity and is an important risk factor for cardiovascular disease-related mortality. However, the burden of PAD in sub-Saharan Africa is poorly understood.<bold>Objective: </bold>To assess epidemiological and clinical reports regarding PAD from sub-Saharan Africa such that the regional epidemiology and management of PAD could be described and recommendations offered.<bold>Evidence Review: </bold>A systematic search in PubMed, Medline, Embase, the Cumulative Index to Nursing and Allied Health Literature, and Google Scholar for reports pertaining to the epidemiology and/or management of PAD in sub-Saharan Africa was performed. Reports that met inclusion criteria were sorted into 3 categories: population epidemiology, clinical epidemiology, and surgical case series. Findings were extracted and described.<bold>Findings: </bold>The search returned 724 records; of these, 16 reports met inclusion criteria. Peripheral arterial disease epidemiology and/or management was reported from 10 of the 48 sub-Saharan African countries. Peripheral arterial disease prevalence ranged from 3.1% to 24% of adults aged 50 years and older and 39% to 52% of individuals with known risk factors (eg, diabetes). Medical management was only described by 2 reports; both documented significant undertreatment of PAD as a cardiovascular disease risk factor. Five surgical case series reported that trauma and diabetes-related complications were the most common indications for vascular surgery.<bold>Conclusions and Relevance: </bold>The prevalence of PAD in sub-Saharan Africa may be equal to or higher than that in high-income countries, exceeding 50% in some high-risk populations. In addition to population-based studies that better define the PAD burden in sub-Saharan Africa, health systems should consider studies and action regarding risk factor mitigation, targeted screening, medical management of PAD, and defining essential vascular care.
- Subjects
SUB-Saharan Africa; AGE distribution; PERIPHERAL vascular diseases; RESEARCH funding; SURVEYS; SYSTEMATIC reviews; DISEASE prevalence; DISEASE complications
- Publication
JAMA Surgery, 2016, Vol 151, Issue 6, p564
- ISSN
2168-6254
- Publication type
journal article
- DOI
10.1001/jamasurg.2016.0446