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- Title
The efficacy of early propranolol administration at reducing PTSD symptoms in pediatric injury patients: A pilot study.
- Authors
Nugent, Nicole R.; Christopher, Norman C.; Crow, John P.; Browne, Lorin; Ostrowski, Sarah; Delahanty, Douglas L.
- Abstract
Initial research supports the use of propranolol to prevent posttraumatic stress disorder (PTSD); research has not examined pharmacological prevention for children. Twenty-nine injury patients (ages 10–18 years old) at risk for PTSD were randomized to a double-blind 10-day trial of propranolol or placebo initiated within 12 hours postadmission. Six-week PTSD symptoms and heart rate were assessed. Although intent-to-treat analyses revealed no group differences, findings supported a significant interaction between gender and treatment in medication-adherent participants, ΔR2 = .21. Whereas girls receiving propranolol reported more PTSD symptoms relative to girls receiving placebo, ΔR2 = .44, boys receiving propranolol showed a nonsignificant trend toward fewer PTSD symptoms than boys receiving placebo, ΔR2 = .32. Findings inform gender differences regarding pharmacological PTSD prevention in youth.
- Subjects
PROPRANOLOL; TREATMENT of post-traumatic stress disorder; CHILDREN'S injuries; PHARMACOLOGY; BLIND experiment; PLACEBOS; GENDER differences (Psychology); PSYCHOLOGICAL stress
- Publication
Journal of Traumatic Stress, 2010, Vol 23, Issue 2, p282
- ISSN
0894-9867
- Publication type
Article
- DOI
10.1002/jts.20517