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- Title
Hybrid bacterial cellulose‐collagen membranes production in culture media enriched with antioxidant compounds from plant extracts.
- Authors
Fernandes, Isabela de Andrade Arruda; Maciel, Giselle Maria; Oliveira, Anna Lou Mucharski Strafit; Miorim, Avany Judith Ferraro; Fontana, Jose Domingos; Ribeiro, Valéria Rampazzo; Haminiuk, Charles Windson Isidoro
- Abstract
Bioactive, structural, and mechanical properties were measured of a cellulose biopolymer produced by Gluconacetobacter xylinus using hydrolyzed collagen and phenolic compounds from teas and grape pomace (GP) in an optimized culture medium. Biopolymers were impregnated with an antibiotic to investigate possible antibacterial activities. Hybrid bacterial cellulose (BC)‐collagen membranes obtained from cultures with green tea and a ternary mixture (TM) of teas with GP presented a high concentration of phenolic compounds (879.7 and 1312.8 mg gallic acid equivalent per liter) and antioxidant activity (973.3 and 575.9 mmol/g), respectively. BC membranes included a nanodimensional network of microfibrils, and the addition of hydrolyzed collagen in the TM of teas in situ resulted in thicker structures with improved mechanical properties. BC‐collagen membranes pretreated with cephalexin exhibited significant inhibition against Escherichia coli and Staphylococcus aureus. The enrichment of the culture media with plant phenolic compounds and collagen resulted in the formation of hybrid BC membranes in a shorter time when compared to those produced without these components. Membranes modified with bioactive compounds in situ and antibiotics ex situ can be turned into potential products for application in biomaterials with antioxidant activity.
- Subjects
GALLIC acid; CELLULOSE synthase; BACTERIAL cell walls; PLANT extracts; PLANT growing media; PHENOLS; BIOACTIVE compounds
- Publication
Polymer Engineering & Science, 2020, Vol 60, Issue 11, p2814
- ISSN
0032-3888
- Publication type
Article
- DOI
10.1002/pen.25514