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- Title
Increased neutrophil lifespan in patients with congestive heart failure.
- Authors
Tracchi, Irene; Ghigliotti, Giorgio; Mura, Marzia; Garibaldi, Silvano; Spallarossa, Paolo; Barisione, Chiara; Boasi, Valentina; Brunelli, Michele; Corsiglia, Luca; Barsotti, Antonio; Brunelli, Claudio
- Abstract
Aims: Congestive heart failure (CHF) can be thought of as a state of chronic immune activation. Polymorphonuclear neutrophil (PMN) apoptosis is one of the mechanisms responsible for the resolution of inflammation. A reduced PMN apoptotic rate in CHF patients may generate a persistent inflammatory response and hence mediate tissue damage in this group of patients. We aimed to measure levels of spontaneous apoptosis of circulating PMNs in CHF patients and in controls, and to examine whether NYHA class, left ventricular ejection fraction (LV-EF), and laboratory parameters of inflammation, endothelial damage, and of liver and renal function, could predict the rate of PMN apoptosis in CHF patients.
- Subjects
NEUTROPHILS; CONGESTIVE heart failure; HEART diseases; APOPTOSIS; INFLAMMATION; PATIENTS
- Publication
European Journal of Heart Failure, 2009, Vol 11, Issue 4, p378
- ISSN
1388-9842
- Publication type
Article
- DOI
10.1093/eurjhf/hfp031