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- Title
Lipid droplets as the genetic nexus of fatty liver.
- Authors
Mann, Jake P.; Romeo, Stefano; Valenti, Luca
- Abstract
As highlighted in this study there is a trend towards association with ALT on gene burden testing6 and common variants in or near these genes are also associated with related metabolic traits, for example, serum lipid profile.15 As they have been robustly and causally implicated in the pathogenesis of progressive fatty liver disease, these lipid metabolism genes (and their respective pathways) are strong candidates for therapeutic targets. I CIDEB i has recently been implicated in somatic mutations in fatty liver and is a hepatocyte-specific lipid droplet protein. Non-alcoholic fatty liver disease (NAFLD) has become the leading cause of liver damage worldwide and is rapidly becoming the leading cause of end-stage liver disease in the USA. A range of exome-wide and genome-wide association studies (GWAS) have identified common variants (>1% prevalence) implicated in all stages of NAFLD.1 Approximately 10 genes have been robustly implicated in fatty liver at genome-wide significance.
- Subjects
FATTY liver; NON-alcoholic fatty liver disease; LIPIDS; DISEASE risk factors; PERILIPIN
- Publication
Liver International, 2022, Vol 42, Issue 12, p2594
- ISSN
1478-3223
- Publication type
Article
- DOI
10.1111/liv.15460