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- Title
Novel concept of "sequential particle radiotherapy" with atezolizumab plus bevacizumab for hepatocellular carcinoma with portal vein tumor thrombus.
- Authors
Komatsu, Shohei; Terashima, Kazuki; Ishihara, Nobuaki; Matsuo, Yoshiro; Kido, Masahiro; Yanagimoto, Hiroaki; Toyama, Hirochika; Tokumaru, Sunao; Okimoto, Tomoaki; Fukumoto, Takumi
- Abstract
Owing to the high objective response rate of atezolizumab plus bevacizumab (Atez/Bev) for hepatocellular carcinoma (HCC), the concept of sequential conversion to local treatment has recently become mainstream. The conversion concept is mainly applied to Barcelona Clinic for Liver Cancer (BCLC) stage B cases, and radiotherapy is rarely considered as a conversion local treatment. We herein report three patients who were treated with the novel concept of "sequential particle radiotherapy," consisting of Atez/Bev therapy followed by particle radiotherapy (PRT) for HCC with advanced portal vein tumor thrombus (Vp3/4 PVTT). All patients achieved partial response radiologically and were switched to PRT. All patients were recurrence free at 1 year after the introduction of Atez/Bev therapy without any additional treatment. This upcoming combination strategy includes the advocacy of sequential concepts for BCLC stage C cases and the introduction of PRT as a local treatment after Atez/Bev.
- Subjects
BARCELONA (Spain); PORTAL vein; ATEZOLIZUMAB; BEVACIZUMAB; THROMBOSIS; RADIOTHERAPY; PORTAL vein diseases; HEPATOCELLULAR carcinoma
- Publication
Surgery Today, 2024, Vol 54, Issue 8, p972
- ISSN
0941-1291
- Publication type
Article
- DOI
10.1007/s00595-024-02805-1