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- Title
Reduction of parasitism tissue by treatment of mice chronically infected with Trypanosoma cruzi with lignano lactones.
- Authors
Esperandim, Viviane Rodrigues; Silva Ferreira, Daniele; Saraiva, Juliana; Silva, Márcio; Costa, Eveline; Pereira, Ana; Bastos, Jairo; Albuquerque, Sérgio
- Abstract
The reduction of parasitism tissue upon treatment with two lignano lactones, namely (−)- cubebin (CUB) and (−)-hinokinin (HNK), was evaluated in the chronic phase of Chagas’ disease by quantifying the enzyme β-galactosidase expressed by the CL B5 clone strain of Trypanosoma cruzi. Tissue karyometry was also performed. Treatment with the assessed lignans led to a larger reduction in parasitism tissue in all evaluated organs, compared with benznidazole (BZN). Oral treatment with CUB or HNK was more effective. Karyometry results demonstrated that the infected control animals had increased nuclear area compared with uninfected controls, indicating cellular hypertrophy. Results also revealed that use of CUB or HNK was able to significantly prevent this increase, and a slight decrease in the nuclear area was observed, compared with mice treated with BZN. Taken together, these data demonstrate that CUB and HNK could be considered as potential compounds for the development of new drugs for treatment of Chagas’ disease.
- Subjects
CHAGAS' disease; TRYPANOSOMA cruzi; PARASITISM; LACTONES; ORAL drug administration; LABORATORY mice; HYPERTROPHY; KARYOMETRY
- Publication
Parasitology Research, 2010, Vol 107, Issue 3, p525
- ISSN
0932-0113
- Publication type
Article
- DOI
10.1007/s00436-010-1885-z