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- Title
Structure-activity relationships of organosulfur compounds as inhibitors of cytochrome P450 1-mediated activation of benzo[a]pyrene in a human cell model.
- Authors
Kim, Hyun Jung; Chun, Hyang Sook
- Abstract
Twelve naturally-occurring organosulfur compounds were investigated as inhibitors of cytochrome P450 1 (CYP450 1)-mediated activation of benzo[a]pyrene (B[a]P) in human hepatoma (HepG2) cells. Inhibition depended on the presence of a diallyl group and the number of S atoms. Diallyl trisulfide (DATS), with a diallyl group and three S atoms, had the highest activity with an IC50 of 0.4 mM, and 1.5-fold higher potency than diallyl disulfide (DADS) containing a diallyl group and two S atoms. Organosulfur compounds containing an alkyl group were less effective, or even ineffective, inhibitors of both CYP450 1 and B[a]P-induced cytotoxicity than DADS and DATS. Alliin and S-allyl cysteine containing the S-cysteinyl group had no inhibition.
- Subjects
EFFECT of chemicals on human cell culture; ORGANOSULFUR compounds; CYTOCHROME P-450; BENZOPYRENE; HEPATOCELLULAR carcinoma; LIVER cells; STRUCTURE-activity relationships
- Publication
Biotechnology Letters, 2002, Vol 24, Issue 24, p2041
- ISSN
0141-5492
- Publication type
Article
- DOI
10.1023/A:1021315320245