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- Title
Structure of the receptor for platelet-derived growth factor helps define a family of closely related growth factor receptors.
- Authors
Yarden, Y.; Escobedo, J. A.; Kuang, W-J.; Yang-Feng, T. L.; Daniel, T. O.; Tremble, P. M.; Chen, E. Y.; Ando, M. E.; Harkins, R. N.; Francke, U.; Fried, V. A.; Ullrich, A.; Williams, L. T.
- Abstract
The primary structure of the receptor for platelet-derived growth factor (PDGF), determined by means of cloning a cDNA that encodes the murine pre-PDGF receptor, is closely related to that of the v-kit oncogene product and the receptor for macrophage colony stimulating factor (CSF-1). Common structural features include the presence of long sequences that interrupt the tyrosine-specific protein kinase domains of each molecule. The PDGF and CSF-1 receptors also share a characteristic distribution of extracellular cysteine residues. Ubiquitin is covalently bound to the purified PDGF receptor, the human gene for which is on chromosome 5.
- Publication
Nature, 1986, Vol 323, Issue 6085, p226
- ISSN
0028-0836
- Publication type
Article
- DOI
10.1038/323226a0