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- Title
C ymbopogon martinii essential oil and geraniol at noncytotoxic concentrations exerted immunomodulatory/anti-inflammatory effects in human monocytes.
- Authors
Murbach Teles Andrade, Bruna Fernanda; Conti, Bruno José; Santiago, Karina Basso; Fernandes, Ary; Sforcin, José Maurício
- Abstract
Objectives In traditional medicine, plants have formed the basis of sophisticated systems that have been in existence for thousands of years and still provide mankind with new remedies. C ymbopogon martinii, known as palmarosa, has been used in aromatherapy as a skin tonic due to its antimicrobial properties. It has also used in Ayurvedic medicine for skin problems and to relieve nerve pain. The immunomodulatory action of C . martinii essential oil ( EO) and geraniol was evaluated regarding the production of pro- and anti-inflammatory cytokines (tumour necrosis factor ( TNF)-α and IL-10, respectively) by human monocytes in vitro. Methods Monocyte cultures were incubated with EO or geraniol. After 18 h, cytotoxicity assays were performed using 3-(4,5-dimethyl-thiazol-2-yl)-2,5-diphenyltetrazolium bromide method, and cytokine production was determined by ELISA. Key findings The variables showed no cytotoxic effects on monocytes. TNF-α production was not affected by C . martinii and geraniol, and only the concentration of 5 μg/ml of C . martinii stimulated its production. On the other hand, all concentrations of C . martinii and geraniol increased IL-10 production by human monocytes. Conclusions Data showed that noncytotoxic concentrations of EO and geraniol exerted an anti-inflammatory action by increasing IL-10 production; moreover, geraniol seemed to be probably responsible for EO immunomodulatory activity in our assay condition.
- Subjects
CYMBOPOGON; MONOCYTES; AROMATHERAPY; AYURVEDIC medicine; THERAPEUTICS
- Publication
Journal of Pharmacy & Pharmacology, 2014, Vol 66, Issue 10, p1491
- ISSN
0022-3573
- Publication type
Article
- DOI
10.1111/jphp.12278