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- Title
Association of polymorphisms and haplotypes in the 5′ region of COLIA1 gene with the risk of osteoporotic fractures in Russian women from Volga-Ural region.
- Authors
Selezneva, L. i.; Khusainova, R. I.; Nurligayanov, R. Z.; Fazlyeva, E. A.; Usenko, K. P.; Lesnyak, O. M.; Khusnutdinova, E. K.
- Abstract
The analysis of −1997G/T, −1663indelT, and +1245G/T polymorphic loci of the 5′-region of COLIA1 gene in 124 females aged from 50 to 70 years old with low numbers of traumatic fractures as well as 150 healthy individuals from Volga-Ural region has been conducted. The association of −1663indelT and +1245G/T loci with the risk of osteoporotic fractures has been discovered. It has been shown that −1997*G*G/−1663*I*D/+1245*G*T genotype combination and −1997*G/−1663*D/+1245*T haplotype can be considered as markers for fracture development.
- Subjects
GENETIC polymorphisms; OSTEOPOROSIS; BONE fractures; GENOTYPE-environment interaction; BIOMARKERS; GENETIC research
- Publication
Russian Journal of Genetics, 2008, Vol 44, Issue 2, p180
- ISSN
1022-7954
- Publication type
Article
- DOI
10.1134/S1022795408020099