We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
The Structure of a Conserved Region of Porcine Genome, Represented in Human Genome by Chromosome 17.
- Authors
Larkin, D. M.; Astakhova, N. M.; Kozhin, A. Yu.; Karamisheva, T. V.; Rubtsov, N. B.; Kuznetsov, S. B.; Zhdanova, N. S.
- Abstract
Radiation mapping of nine genes (H3F3B, HLR1, MYL4, STAT5B, THRA1, TOP2A, MCP1, NF1, and MPO) to porcine chromosome 12 was carried out. Also, subchromosomal location of the NF1 gene along with the two loci containing the DNA sequences homologous to the DNA of the two human BAC clones was determined. The NF1 position was ascertained via microdissection of chromosome 12 with subsequent PCR amplification of the gene fragment with specific primers. BAC clones were mapped using FISH. Comparative analysis of the gene order in porcine chromosome 12 and in the homologous human chromosome 17 was performed. It was demonstrated that the gene orders in these chromosomes differed relative to the position of the MPO gene.
- Subjects
HUMAN genome; CHROMOSOMES; DNA; COMPARATIVE studies; PORCINE somatotropin; HUMAN chromosomes
- Publication
Russian Journal of Genetics, 2004, Vol 40, Issue 7, p782
- ISSN
1022-7954
- Publication type
Article
- DOI
10.1023/B:RUGE.0000036528.04040.47