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- Title
Chromosome crosstalk in three dimensions.
- Authors
Göndör, Anita; Ohlsson, Rolf
- Abstract
The genome forms extensive and dynamic physical interactions with itself in the form of chromosome loops and bridges, thus exploring the three-dimensional space of the nucleus. It is now possible to examine these interactions at the molecular level, and we have gained glimpses of their functional implications. Chromosomal interactions can contribute to the silencing and activation of genes within the three-dimensional context of the nuclear architecture. Technical advances in detecting these interactions contribute to our understanding of the functional organization of the genome, as well as its adaptive plasticity in response to environmental changes during development and disease.
- Subjects
CHROMOSOMES; CELL nuclei; GENE silencing; HUMAN genome; PHYSIOLOGICAL adaptation; GENETIC regulation; GENOMES; GENETICS; PHYSIOLOGY
- Publication
Nature, 2009, Vol 461, Issue 7261, p212
- ISSN
0028-0836
- Publication type
Article
- DOI
10.1038/nature08453