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- Title
Poly(methacrylic Acid)-Cellulose Brushes as Anticancer Porphyrazine Carrier.
- Authors
Krasnopeeva, Elena L.; Melenevskaya, Elena Yu.; Klapshina, Larisa G.; Shilyagina, Natalia Yu.; Balalaeva, Irina V.; Smirnov, Nikolay N.; Smirnov, Michael A.; Yakimansky, Alexander V.
- Abstract
The prospective strategy for treatment of cancer is based on the application of nano-sized macromolecular carriers, which are able penetrate inside and can be accumulated within tumor tissue. In this work graft copolymers of cellulose and poly(methacrylic acid) has been prepared and tested as a nanocontainers for the delivery of drug to tumor. For this purpose, two derivatives of porphyrazine suitable for photodynamic cancer therapy were loaded into prepared polymer brush. Fluorescence imaging was applied for monitoring of accumulation of porphyrazine in the CT26 murine colon carcinoma. The selective accumulation of cellulose brush loaded with porphyrazine in tumor was demonstrated by fluorescence intensity contrast between the tumor area and normal tissues. The tumor growth rate after photodynamic therapy were assessed and inhibition of its growth was revealed.
- Subjects
METHACRYLIC acid; GRAFT copolymers; PHOTODYNAMIC therapy; TUMOR growth; CANCER treatment; CELLULOSE
- Publication
Nanomaterials (2079-4991), 2021, Vol 11, Issue 8, p1997
- ISSN
2079-4991
- Publication type
Article
- DOI
10.3390/nano11081997