We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Epigenetic clocks suggest accelerated aging in patients with isolated REM Sleep Behavior Disorder.
- Authors
Baldelli, Luca; Pirazzini, Chiara; Sambati, Luisa; Ravaioli, Francesco; Gentilini, Davide; Calandra-Buonaura, Giovanna; Guaraldi, Pietro; Franceschi, Claudio; Cortelli, Pietro; Garagnani, Paolo; Bacalini, Maria Giulia; Provini, Federica
- Abstract
Isolated REM Sleep Behavior Disorder (iRBD) is the strongest prodromal marker for α-synucleinopathies. Overt α-synucleinopathies and aging share several mechanisms, but this relationship has been poorly investigated in prodromal phases. Using DNA methylation-based epigenetic clocks, we measured biological aging in videopolysomnography confirmed iRBD patients, videopolysomnography-negative and population-based controls. We found that iRBDs tended to be epigenetically older than controls, suggesting that accelerated aging characterizes prodromal neurodegeneration.
- Subjects
RAPID eye movement sleep; SLEEP disorders; EPIGENETICS
- Publication
NPJ Parkinson's Disease, 2023, Vol 9, Issue 1, p1
- ISSN
2373-8057
- Publication type
Article
- DOI
10.1038/s41531-023-00492-2