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- Title
Gas Chromatography—High-Temperature Proton-Transfer Reaction Mass Spectrometry as a Novel Tool for Forensic Drug Testing.
- Authors
Reinstadler, Vera; Gutmann, Rene; Pitterl, Florian; Winkler, Klaus; Oberacher, Herbert
- Abstract
Proton-transfer reaction mass spectrometry (PTR-MS) is a versatile tool for the mass spectrometric analysis of organic molecules in gaseous samples. Due to its operation principle, PTR-MS is a soft ionization technique generating spectral data typically rich in protonated molecule information. Most of the currently reported PTR-MS applications are designed to determine volatile compounds. Herein, we present a redesigned instrumental setup termed "high-temperature (HT)-PTR-MS" with improved capabilities for the analysis of low-volatile compounds. The developed HT-PTR-MS prototype was successfully hyphenated with gas chromatography (GC) to enable qualitative and quantitative analysis of licit and illicit drugs in human blood/plasma samples. Different kinds of spiked and authentic samples were used to evaluate the performance of the GC-HT-PTR-MS in forensic drug testing. Benchmarking against GC-MS with electron ionization demonstrated the improved detection capabilities of GC-HT-PTR-MS in screening applications. On average, one order of magnitude lower limits of detection/identification were reached. Clearly, GC-HT-PTR-MS has the vast potential to complement or even replace established mass spectrometric techniques in forensic drug analysis.
- Subjects
MASS spectrometry; GAS chromatography; DRUG use testing; ELECTRON impact ionization; DRUG analysis; ENVIRONMENTAL forensics
- Publication
Separations (2297-8739), 2022, Vol 9, Issue 11, p328
- ISSN
2297-8739
- Publication type
Article
- DOI
10.3390/separations9110328