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- Title
Accurate simultaneous quantification of liver steatosis and iron overload in diffuse liver diseases with MRI.
- Authors
França, Manuela; Alberich-Bayarri, Ángel; Martí-Bonmatí, Luis; Oliveira, Pedro; Costa, Francisca; Porto, Graça; Vizcaíno, José; Gonzalez, Javier; Ribeiro, Eduardo; Oliveira, João; Pessegueiro Miranda, Helena
- Abstract
Purpose: To evaluate the diagnostic performances of 3 Tesla multi-echo chemical shift-encoded gradient echo magnetic resonance (MECSE-MR) imaging to simultaneously quantify liver steatosis and iron overload in a wide spectrum of diffuse liver diseases having biopsy as reference standard. Methods: MECSE-MR-acquired images were used to calculate fat fraction and iron content in a single breath-hold in 109 adult patients. Proton density fat fraction (PDFF) was prospectively estimated using complex-based data reconstruction with multipeak fat modeling. Water R2* was used to estimate iron content. Biopsy was obtained in all cases, grading liver steatosis, siderosis, inflammation, and fibrosis. Differences in PDFF and R2* values across histopathological grades were analyzed, and ROC curves analyses evaluated the MR diagnostic performance. Results: Calculated fat fraction measurements showed significant differences ( p < 0.001) among steatosis grades, being unaffected by the presence of inflammation or fibrosis ( p ≥ 0.05). A strong correlation was found between fat fraction and steatosis grade ( R = 0.718, p < 0.001). Iron deposits did not affect fat fraction quantitation ( p ≥ 0.05), except in cases with severe iron overload (grade 4). A strong positive correlation was also observed between R2* measurements and iron grades ( R = 0.704, p < 0.001). Calculated R2* values were not different across grades of steatosis, inflammation, and fibrosis ( p ≥ 0.05). Conclusion: A MECSE-MR sequence simultaneously quantifies liver steatosis and siderosis, regardless coexisting liver inflammation or fibrosis, with high accuracy in a wide spectrum of diffuse liver disorders. This sequence can be acquired within a single breath-hold and can be implemented in the routine MR evaluation of the liver.
- Subjects
FATTY degeneration; LIVER; FATTY liver; LIVER biopsy; FIBROSIS; DIAGNOSIS; MAGNETIC resonance imaging
- Publication
Abdominal Radiology, 2017, Vol 42, Issue 5, p1434
- ISSN
2366-004X
- Publication type
Article
- DOI
10.1007/s00261-017-1048-0