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- Title
Bone and Energy Metabolism.
- Authors
Sujin Lee; Yumie Rhee
- Abstract
Bone remodeling requires a large amount of energy, and is regulated by various hormones. Leptin, produced by adipocytes, is a well-known regulator of energy balance and is also involved in controlling bone mass through interaction with the central nervous system. Serotonin, downstream of leptin, is also emerging as a candidate for controlling energy balance and bone metabolism. Currently, bone is also considered to be an endocrine regulator of energy metabolism. Osteocalcin, secreted from osteoblasts, is known to be a key regulator of glucose and fat metabolism. In this review, we describe a novel concept that asserts that there exists a biological link between bone and energy metabolism, and we summarize what is currently known about the relationship between bone and energy metabolism.
- Subjects
BONE metabolism; ENERGY metabolism; FAT cells; BIOENERGETICS; SEROTONIN; OSTEOCALCIN; NEUROTRANSMITTERS
- Publication
Journal of Korean Diabetes, 2013, Vol 14, Issue 4, p174
- ISSN
2233-7431
- Publication type
Article
- DOI
10.4093/jkd.2013.14.4.174