We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
BASAL CELL CARCINOMA DEVELOPMENT AFTER COMBINED ADMINISTRATION OF LISINOPRIL AND TAMSULOSIN: LINKS TO PHOTOCARCINOGENESIS AND NITROSOGENESIS IN THE CONTEXT OF PHARMACO-ONCOGENESIS.
- Authors
Tchernev, G.; Todorov, I.; Ivanov, L.; Kordeva, S.
- Abstract
The association of nitrosogenesis with skin cancer, and in particular with keratino-cytic forms of skin cancer, is primarily or mainly determined by the activation of carcinogenesis and/or mutagenesis. The mutagenic and carcinogenic potential of nitrosamines/NDSRIs identified as contaminants in drugs worldwide varies considerably. Data for some of their representatives are scarce (and sometimes) to completely lacking as official data. The pharmaco-oncogenesis of skin cancer is mainly due to the presence of nitrosamines in the drugs, although the latter are not defined and labelled even as an availability. The overlap of the mutant genes (RAS/p53) in patients with basal cell carcinomas with those induced by some of the nitrosamines/NDSRIs identified in the drugs (again p53/RAS) are also further evidence of their potential mutagenic/carcinogenic action in humans. We present a 92-year-old patient who developed a short-term basal cell carcinoma under the right lower eyelid, treated successfully surgically by island flap, as part of polymedication with tamsulosin and perindopril. We analyze the potential role of nitroso-tamsulosin and nitroso-perindopril in the context of nitrosogen- esis/pharmaco-oncogenesis concerning skin cancer. Elimination regimens for nitrosamines/NDSRIs in drugs worldwide should be more than strictly mandatory because their short-term intake in the context of polymedication polycontamination could lead to the development of keratinocytic cancer, analogously to the case we presented next. Even more disturbing are the latest scientific data that alarm about certain nitrosamines that are also strong photocarcinogens.
- Subjects
BASAL cell carcinoma; SKIN cancer; LISINOPRIL; TAMSULOSIN; NITROSOAMINES; MUTAGENESIS
- Publication
Medical Review / Meditsinski Pregled, 2024, Vol 60, Issue 4, p67
- ISSN
1312-2193
- Publication type
Article