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- Title
Aggressive behavior of indolent non-Hodgkin lymphoma – case report.
- Authors
Onisâi, Minodora; Iordan, Iuliana; Neagu, Ana Maria; Nicorescu, Iuliana; Vlădăreanu, Ana-Maria
- Abstract
Follicular lymphoma (FL) is the most common indolent non-Hodgkin lymphoma. The clinical behavior is hete rogeneous, with many clinical scenarios, including long-term stable disease, disease progression, histological trans forma tion, and early or tardive relapses after treatment. The most important predictors for disease aggressivity are the Fol licular Lymphoma International Prognostic Index, the his to lo gical subtype, the proliferation index, the Ann Arbor sta ging, the tumoral burden, the relapse time and the his to lo gical transformation. The treatment options in FL are numerous, ranging from watchful waiting to radiation therapy, aggressive chemoimmunotherapy, and even stem cell transplantation. The treatment is chosen based on disease (stage, grade) and patient’s characteristics (age, comorbidities, preference). We present the case of a 69-yearold patient diagnosed with grade 3a follicular lym pho ma, treated with chemoimmunotherapy and ra dia tion therapy, with an aggressive evolution. Although she obtained a good response after therapy, the disease relapsed rapidly. The management was complicated even more when the patient developed an indolent SARS-CoV-2 infection.
- Subjects
ANN Arbor (Mich.); NON-Hodgkin's lymphoma; CANCER invasiveness; FOLLICULAR lymphoma; STEM cell transplantation; WATCHFUL waiting
- Publication
Oncolog-Hematolog, 2021, Issue 55, p31
- ISSN
2066-8716
- Publication type
Article
- DOI
10.26416/onhe.55.2.2021.5019