We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Antihypertensive Use and Recurrent Falls in Community-Dwelling Older Adults: Findings From the Health ABC Study.
- Authors
Marcum, Zachary A.; Perera, Subashan; Newman, Anne B.; Thorpe, Joshua M.; Switzer, Galen E.; Gray, Shelly L.; Simonsick, Eleanor M.; Shorr, Ronald I.; Bauer, Douglas C.; Castle, Nicholas G.; Studenski, Stephanie A.; Hanlon, Joseph T.; Health ABC Study
- Abstract
<bold>Background: </bold>Despite wide-spread use of antihypertensives in older adults, the literature is unclear about their association with incident recurrent falls over time.<bold>Methods: </bold>Health, Aging and Body Composition study participants (n = 2,948) who were well functioning at baseline (1997) were followed to Year 7 (2004). The main outcome was recurrent falls (≥2) in the ensuing 12 months. Antihypertensive use was examined as: (a) any versus none, (b) long- versus short-term (≥2 vs <2 years), and by (c) summated standardized daily dose (SDD; 1 = maximum recommended daily dose for one antihypertensive), and (d) subclass.<bold>Results: </bold>Controlling for potential demographic, health status/behavior and access to care confounders, we found no increase in risk of recurrent falls in antihypertensive users compared to nonusers (adjusted odds ratio [AOR] = 1.13; 95% CI = 0.88-1.46), or those taking higher SDDs or for longer durations. Only those using a loop diuretic were found to have a modest increased risk of recurrent falls (AOR = 1.50; 95% CI = 1.11-2.03).<bold>Conclusions: </bold>Antihypertensive use overall was not statistically significantly associated with recurrent falls after adjusting for important confounders. Loop diuretic use may be associated with recurrent falls and needs further study.
- Subjects
GROUP homes for older people; ACCIDENTAL falls in old age; ANTIHYPERTENSIVE agents; EPIDEMIOLOGY; CONFOUNDING variables; ODDS ratio; LOOP diuretics; ACCIDENTAL falls; LONGITUDINAL method; INDEPENDENT living
- Publication
Journals of Gerontology Series A: Biological Sciences & Medical Sciences, 2015, Vol 70, Issue 12, p1562
- ISSN
1079-5006
- Publication type
journal article
- DOI
10.1093/gerona/glv095