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- Title
Role of Thrombospondin-2 in Refractory Epilepsy.
- Authors
SAĞLAM, Serra; SELEK, Şahabettin; UYGUR ŞAHİN, Türkan; SARIKAYA, Ufuk
- Abstract
Introduction: Epilepsy is a common chronic disease characterized by repetitive convulsions related to sudden, abnormal discharges of neurons that unfavorably influence neurobiological, cognitive, psychological, and social abilities. Although some treatment choices, including medical and surgical procedures, exist, there are refractory cases as well. Our aim was to explain the role of thrombospondin-2 (TSP), a glycoprotein produced by astrocytes in the central nervous system, in refractory epilepsy. Method: In this prospective study, 82 children (<18 years old) -regardless of their sex-that attended Bezmialem Vakıf University Hospital between August 2023 and January 2024 were included and classified into three groups: an epilepsy group (n=34) whose convulsions were under control with 1 drug, a refractory epilepsy group (n=28) that still had convulsions despite using two or more drugs, and a healthy group (n=20) that had no chronic disease. Children who had any chronic disease other than epilepsy or any lesion detected in cranial MR were excluded. TSP-2 levels in serum samples were analyzed using a commercial ELISA kits and compared between each group using the Kruskal-Wallis H test. Results: Mean age was 2.17±0.66 in epilepsy group, 2.02±0.80 in refractory epilepsy group and 2.15±0.43 in control group. There was no significant difference between the mean ages of the groups (p=0.55). The mean TSP-2 level was 2.73±0.75 in epilepsy group, 2.31±0.73 in refractory epilepsy group and 1.77±0.80 in control group. There was a statistically significant difference between the TSP-2 levels of the groups (p<0.001). Conclusion: The TSP-2 levels of both epilepsy and refractory epilepsy patients were increased, whereas the mean TSP-2 levels of the epilepsy group were higher than those of the refractory epilepsy group. Further studies are essential to confirm our results.
- Subjects
EPILEPSY; PEOPLE with epilepsy; CENTRAL nervous system; SOCIAL skills; KRUSKAL-Wallis Test
- Publication
Bezmialem Science, 2024, Vol 13, pS10
- ISSN
2148-2373
- Publication type
Article