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- Title
Melatonin in Neurodevelopmental Disorders: A Critical Literature Review.
- Authors
Feybesse, Cyrille; Chokron, Sylvie; Tordjman, Sylvie
- Abstract
The article presents a review of the relationships between melatonin and neurodevelopmental disorders. First, the antioxidant properties of melatonin and its physiological effects are considered to understand better the role of melatonin in typical and atypical neurodevelopment. Then, several neurodevelopmental disorders occurring during infancy, such as autism spectrum disorder or neurogenetic disorders associated with autism (including Smith–Magenis syndrome, Angelman syndrome, Rett's syndrome, Tuberous sclerosis, or Williams–Beuren syndrome) and neurodevelopmental disorders occurring later in adulthood like bipolar disorder and schizophrenia, are discussed with regard to impaired melatonin production and circadian rhythms, in particular, sleep–wake rhythms. This article addresses the issue of overlapping symptoms that are commonly observed within these different mental conditions and debates the role of abnormal melatonin production and altered circadian rhythms in the pathophysiology and behavioral expression of these neurodevelopmental disorders.
- Subjects
LITERATURE reviews; AUTISTIC children; RETT syndrome; NEURAL development; AUTISM spectrum disorders; MELATONIN
- Publication
Antioxidants, 2023, Vol 12, Issue 11, p2017
- ISSN
2076-3921
- Publication type
Article
- DOI
10.3390/antiox12112017