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- Title
Amidinoquinoxaline-Based Nitrones as Lipophilic Antioxidants.
- Authors
Gruber, Nadia; Orelli, Liliana; Minnelli, Cristina; Mangano, Luca; Laudadio, Emiliano; Mobbili, Giovanna; Stipa, Pierluigi
- Abstract
The potential of nitrones (N-oxides) as therapeutic antioxidants is due to their ability to counteract oxidative stress, mainly attributed to their action as radical scavengers toward C- and O-centered radicals. Among them, nitrones from the amidinoquinoxaline series resulted in interesting derivatives, due to the ease with which it is possible to introduce proper substituents within their structure in order to modulate their lipophilicity. The goal is to obtain lipophilic antioxidants that are able to interact with cell membranes and, at the same time, enough hydrophilic to neutralize those radicals present in a water compartment. In this work, the antioxidant efficacy of a series of amidinoquinoxaline nitrones has been evaluated regarding the oxidation of 2-deoxyribose and lipid peroxidation. The results have been rationalized on the basis of the different possible mechanisms involved, depending on some of their properties, such as lipophilicity, the ability to scavenge free radicals, and to undergo single electron transfer (SET) reactions.
- Subjects
NITRONES; LIPOPHILICITY; FREE radicals; ANTIOXIDANTS; CHARGE exchange; CELL membranes
- Publication
Antioxidants, 2021, Vol 10, Issue 8, p1185
- ISSN
2076-3921
- Publication type
Article
- DOI
10.3390/antiox10081185