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- Title
Yenidoğan Sarılığında Glukoz 6 Fosfat Dehidrogenaz Enzim Eksikliği.
- Authors
YAPRAK, Deniz; BOZAT, Ali Dinç; ÇALIŞICI, Erhan; GÜRSEL, Orhan; SAYGILI KARAGÖL, Belma
- Abstract
Objective: Glucose-6-phosphate dehydrogenase (G6PD) deficiency is the most common enzymatic disorder of erythrocytes and manifested by anemia and jaundice. This study planned to investigate the effect of G6PD deficiency on newborn jaundice in the neonatal period. Material and Methods: Demographic and clinical characteristics, and laboratory parameters of 130 infants' who were treated for newborn jaundice and had G6PD enzyme tests further analyzed retrospectively. Cases with G6PD enzyme deficiency were compared to those without. Results: Glucose-6-phosphate dehydrogenase deficiency was found in 22 (16.9%) infants and their mean G6PD enzyme level was 2.7±1.7 U/g Hb (N: 8-16). Mean peak bilirubin level was higher in patients with G6PD deficiency (21.6±4.1 vs 19.04±3.5 mg/dL, p=0.003). Duration of phototherapy was longer in patients with G6PD deficiency than without (3.1±0.7 vs 2.5±0.7 days, p=0.001). The levels of G6PD (Male 2.1vs Female: 4.04 U/g Hb; p=0.010), hemoglobin (Male: 16.4±1.9 vs Female: 20.7±1.3 g/dL; p<0.001) and hematocrit (Male: 49.3±4.7 vs Female: 61.9±3.7; p<0.001) were lower in the male infants with G6PD enzyme deficiency. There was a positive correlation between hemoglobin (r=0.62, p=0.013) and hematocrit (r=0.54, p=0.012) and serum G6PD levels in the infants with G6PD enzyme deficiency. Duration of phototherapy (Male: 3.4±0.6 vs Female: 2.4±0.5 days; p=0.002) and jaundice recovery (Male: 8.5±2.9 vs Female: 6.4±1.2 days; p=0.002) were longer in the male infants. Conclusion: Glucose-6-phosphate dehydrogenase deficiency is a condition lead to severe jaundice and prolong the phototherapy duration in the neonatal period. Glucose-6-phosphate dehydrogenase deficiency should be kept in mind in the infants with severe jaundice regardless of gender.
- Publication
Journal of Pediatric Disease / Türkiye Çocuk Hastalıkları Dergisi, 2022, Vol 16, Issue 2, p100
- ISSN
1307-4490
- Publication type
Article
- DOI
10.12956/tchd.821868