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- Title
A simple method for detection of imprinting effects based on case–parents trios.
- Authors
Zhou, J-Y.; Hu, Y-Q.; Fung, W. K.
- Abstract
Using data from families in which marker genotypes are known for the father, the mother and the affected offspring, a simple statistic for testing for imprinting effects is developed. The statistic considers whether the expected number of families in which the father carries more copies of a particular marker allele than the mother is equal to the expected number of families in which the mother carries more copies of the allele than the father. The proposed parent-of-origin effects test statistic (POET) is shown to be normally distributed and can be employed to test for imprinting in situations where the marker locus need not be a disease susceptibility locus and where the female and male recombination fractions are sex-specific. A simulation study is conducted to characterize the power of the POET and other properties, and its results show that it is appropriate to employ the POET.Heredity (2007) 98, 85–91. doi:10.1038/sj.hdy.6800906; published online 11 October 2006
- Subjects
GENOMIC imprinting; SEX-linkage (Genetics); GENE mapping; GENETIC polymorphisms; GENOTYPE-environment interaction; GENE expression
- Publication
Heredity, 2007, Vol 98, Issue 2, p85
- ISSN
0018-067X
- Publication type
Article
- DOI
10.1038/sj.hdy.6800906