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- Title
Vrijednosti serumskog kreatinina, Cockcroft-Gault i Modification of Diet in Renal Diseases jednadžbi u bolesnika s arterijskom hipertenzijom.
- Authors
Šečić, Damir; Turohan, Adnan; Begić, Edin; Sokolović, Šekib; Rebić, Damir; Mušija, Ehlimana; Kusturica, Jasna; Ćesić, Aida Kulo; Pepić, Esad; Mušanović, Jasmin; Metović, Azra
- Abstract
Aim: To determine whether there are differences between serum creatinine levels, estimated glomerular filtration rate (GFR) according to the Modification of Diet in Renal Disease Study (MDRD) equation, creatinine clearance, and estimated GFR obtained by the Cockcroft-Gault method related to age, stage, and duration of arterial hypertension. Patients and Methods: The study included 124 patients with arterial hypertension who were examined at the Clinic for Heart, Rheumatism and Blood Vessels, Clinical Center University of Sarajevo. All patients were examined, and data about the duration and stage of hypertension were taken. Kidney function was assessed using serum creatinine, estimated GFR according to the MDRD equation, creatinine clearance estimated by the Cockcroft-Gault method (eCrClCG) and its corrections for body surface area (eCrClCG1.73), body mass index (eCrClCGBMI), both body surface area and body mass index (eCrClCGBMI1.73), and estimated GFR using the Cockcroft-Gault method (eGFRCGBMI1.73). Results: There was a significant difference in values in MDRD equation estimated GFR, eCrClCGBMI, eCrClCGBMI1.73, and eGFRCGBMI1.73 in patients with different stages and durations of hypertension, which was not found by analysis of serum creatinine values. Conclusion: Estimated GFR and eCrCl are more sensitive markers of kidney impairment than serum creatinine values, and their assessment should be introduced as a routine screening in the detection of early stages of chronic kidney disease in primary care settings, especially in patients with arterial hypertension.
- Subjects
BODY surface area; HYPERTENSION; GLOMERULAR filtration rate; BODY mass index; CHRONIC kidney failure
- Publication
Cardiologia Croatica, 2021, Vol 16, Issue 7/8, p257
- ISSN
1848-543X
- Publication type
Article
- DOI
10.15836/ccar2021.257