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- Title
RPEM: Randomized Monte Carlo parametric expectation maximization algorithm.
- Authors
Chen, Rong; Schumitzky, Alan; Kryshchenko, Alona; Nieforth, Keith; Tomashevskiy, Michael; Hu, Shuhua; Garreau, Romain; Otalvaro, Julian; Yamada, Walter; Neely, Michael N.
- Abstract
Inspired from quantum Monte Carlo, by sampling discrete and continuous variables at the same time using the Metropolis–Hastings algorithm, we present a novel, fast, and accurate high performance Monte Carlo Parametric Expectation Maximization (MCPEM) algorithm. We named it Randomized Parametric Expectation Maximization (RPEM). We compared RPEM with NONMEM's Importance Sampling Method (IMP), Monolix's Stochastic Approximation Expectation Maximization (SAEM), and Certara's Quasi‐Random Parametric Expectation Maximization (QRPEM) for a realistic two‐compartment voriconazole model with ordinary differential equations using simulated data. We show that RPEM is as fast and as accurate as the algorithms IMP, QRPEM, and SAEM for the voriconazole model in reconstructing the population parameters, for the normal and log‐normal cases.
- Subjects
ORDINARY differential equations; STOCHASTIC approximation; EXPECTATION-maximization algorithms; PARAMETERS (Statistics); ALGORITHMS
- Publication
CPT: Pharmacometrics & Systems Pharmacology, 2024, Vol 13, Issue 5, p759
- ISSN
2163-8306
- Publication type
Article
- DOI
10.1002/psp4.13113