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- Title
The Interplay Between Monocytes/Macrophages and CD4<sup>+</sup> T Cell Subsets in Rheumatoid Arthritis.
- Authors
Roberts, Ceri A.; Dickinson, Abigail K.; Taams, Leonie S.; Garside, Paul; Ginhoux, Florent
- Abstract
Rheumatoid arthritis (RA) is a chronic inflammatory disease characterized by inflammation of the synovial lining (synovitis). The inflammation in the RA joint is associated with and driven by immune cell infiltration, synovial hyperproliferation, and excessive production of proinflammatory mediators, such as tumor necrosis factor α (TNFα), interferon γ (IFNγ), interleukin (IL)-1β, IL-6, and IL-17, eventually resulting in damage to the cartilage and underlying bone. The RA joint harbors a wide range of immune cell types, including monocytes, macrophages, and CD4+ T cells (both proinflammatory and regulatory). The interplay between CD14+ myeloid cells and CD4+ T cells can significantly influence CD4+ T cell function, and conversely, effector vs. regulatory CD4+ T cell subsets can exert profound effects on monocyte/macrophage function. In this review, we will discuss how the interplay between CD4+ T cells and monocytes/macrophages may contribute to the immunopathology of RA.
- Subjects
RHEUMATOID arthritis; INFLAMMATION; T helper cells
- Publication
Frontiers in Immunology, 2015, Vol 6, p1
- ISSN
1664-3224
- Publication type
Article
- DOI
10.3389/fimmu.2015.00571