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- Title
Increase of CC chemokine receptor 4-positive cells in the peripheral CD4<sup>+</sup> cells in dogs with atopic dermatitis or experimentally sensitized to Japanese cedar pollen.
- Authors
Maeda, S.; Ohmori, K.; Yasuda, N.; Kurata, K.; Sakaguchi, M.; Masuda, K.; Ohno, K.; Tsujimoto, H.
- Abstract
Since dogs frequently develop allergic diseases, similar to those in humans, dogs represent a possible animal model for allergy in humans. In human atopic dermatitis (AD), CC chemokine receptor 4 (CCR4) has been shown to play an important role in the development of allergic inflammation of AD; however, the association between allergic reaction and CCR4 is not well understood in dogs. To examine CCR4 expression in peripheral blood CD4+ cells in dogs that had AD and were experimentally sensitized with Japanese cedar pollen. Peripheral blood mononuclear cells (PBMCs) were isolated from 17 dogs with AD. The proportion of CCR4+ cells in peripheral blood CD4+ cells (CCR4/CD4) was evaluated by flow cytometry and compared with that in 10 healthy dogs. Similarly, in dogs that were experimentally sensitized to Japanese cedar pollen antigen, the proportion of CCR4/CD4 was examined pre- and post-sensitization. The proportion of CCR4/CD4 in dogs with AD was 40.3±3.3%, which was significantly higher than that in normal dogs (23.6±4.3%) ( P<0.01). In the experimentally sensitized dogs, the proportion of CCR4/CD4 was 25.4±2.6% at pre-sensitization and it was significantly increased (29.8±2.9%) at post-sensitization ( P<0.01). The proportion of CCR4+ cells in peripheral blood CD4+ cells was measured in dogs with allergic conditions. The present findings indicate that CCR4+ cells may be involved in the pathogenesis of allergy in dogs as in humans.
- Subjects
DOGS; ALLERGIES; ATOPIC dermatitis; SKIN inflammation; CHEMOKINES; ALLERGENS
- Publication
Clinical & Experimental Allergy, 2004, Vol 34, Issue 9, p1467
- ISSN
0954-7894
- Publication type
Article
- DOI
10.1111/j.1365-2222.2004.02039.x