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- Title
Concurrent Human Papillomavirus-Positive Squamous Cell Carcinoma of the Oropharynx in a Married Couple.
- Authors
Brobst, Tyler D.; García, Joaquín J.; Price, Katharine A.; Gao, Ge; Smith, David I.; Price, Daniel L.
- Abstract
Background. Although alcohol and tobacco use are known risk factors for development of squamous cell carcinoma in the head and neck, human papillomavirus (HPV) has been increasingly associated with this group of cancers. We describe the case of a married couple who presented with HPV-positive oropharynx squamous cell carcinoma within two months of each other. Methods. Tumor biopsies were positive for p16 and high-risk HPV in both patients. Sanger sequencing showed a nearly identical HPV16 strain in both patients. Both patients received chemoradiation, and one patient also underwent transoral robotic tongue base resection with bilateral neck dissection. Results. Both patients showed no evidence of recurrent disease on follow-up PET imaging. Conclusions. New head and neck symptoms should be promptly evaluated in the partner of a patient with known HPV-positive oropharynx cancer. This case expands the limited current literature on concurrent presentation of HPV-positive oropharynx squamous cell carcinoma in couples.
- Subjects
PAPILLOMAVIRUSES; SQUAMOUS cell carcinoma; OROPHARYNX; MARRIED people; NECK dissection; DISEASES; DIAGNOSIS
- Publication
Case Reports in Otolaryngology, 2016, p1
- ISSN
2090-6765
- Publication type
Article
- DOI
10.1155/2016/8481235