We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Antidiabetic activity and chemical characterization of aqueous/ethanol prop roots extracts of Pandanus fascicularis Lam in streptozotocin-induced diabetic rats
- Authors
Rajeswari, Jothimni; Kesavan, Karthikeyan; Jayakar, Balasundaram
- Abstract
Abstract: Objective: To evaluate antidiabetic activity and chemical characterization of aqueous and ethanolic extracts of prop roots of Pandanus fascicularis Lam (P. fascicularis) in streptozotocin (STZ) induced diabetic rats. Methods: Ethanol and aqueous extracts were prepared from P. facicularis by percolation and cold maturation, respectively. Anti diabetic activity of prop roots of P. fascicularis at the dose of 250 mg/kg in STZ (i.p / 60mg/kg body weight) induced diabetic rats. The fasting blood glucose levels were measured at 0, 1, 2 and 3 hrs after the treatment of ethanol and aqueous extracts. The ethanol fraction was then subjected to chromatographic analysis and a compound has been isolated and characterized by IR, 1H-NMR and Mass Spectroscopy. Results: The reduced blood glucose level was significant (P < 0.001) in the dose of 250 mg/kg of ethanol and aqueous extracts of P. fascicularis, when compared with control. The blood glucose level of diabetic control animals after 3 h was (226.00 ± 1.78) mg/kg, whereas it were (102.00 ±1.73) mg/kg and (131.00 ± 1.92) mg/kg for the groups treated with aqueous extract and ethanol extract, respectively. The ethanol fraction was then subjected to chromatographic analysis and a compound has been isolated. The structure of the isolated compound is may be characterized as Hepta deca-5-ene-1-ol by analysis it''s IR, 1H NMR and Mass spectroscopy data. Conclusion: These results demonstrated that aqueous/ethanol extracts of prop roots of P. fascicularis showed significant anti-diabetic activity, consequently this plant might be of value in diabetes treatment.
- Subjects
HYPOGLYCEMIC agents; CHEMICAL composition of plants; AQUEOUS solutions; ETHANOL; PLANT roots; PLANT extracts; PANDANUS; STREPTOZOTOCIN; LABORATORY rats
- Publication
Asian Pacific Journal of Tropical Biomedicine, 2012, Vol 2, Issue s1, pS170
- ISSN
2221-1691
- Publication type
Article
- DOI
10.1016/S2221-1691(12)60152-X