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- Title
Local recall responses in the stomach involving reduced regulation and expanded help mediate vaccine-induced protection against Helicobacter pylori in mice.
- Authors
Becher, Dorit; Deutscher, Michael E.; Simpfendorfer, Kim R.; Wijburg, Odilia L.; Pederson, John S.; Lew, Andrew M.; Strugnell, Richard A.; Walduck, Anna K.
- Abstract
Helicobacter pylori is recognised as the chief cause of chronic gastritis, ulcers and gastric cancer in humans. With increased incidence of treatment failure and antibiotic resistance, development of prophylactic or therapeutic vaccination is a desirable alternative. Although the results of vaccination studies in animal models have been promising, studies in human volunteers have revealed problems such as 'post-immunisation gastritis' and comparatively poor responses to vaccine antigens. The focus of this study was to compare the gastric and systemic cellular immune responses induced by recombinant attenuated Salmonella Typhimurium-based vaccination in the C57BL/6 model of H. pylori infection. Analysis of lymphocyte populations in the gastric mucosa, blood, spleen, paragastric LN and MLN revealed that the effects of vaccination were largely confined to the parenchymal stomach rather than lymphoid organs. Vaccine-induced protection was correlated with an augmented local recall response in the gastric mucosa, with increased proportions of CD4
- Publication
European Journal of Immunology, 2010, Vol 40, Issue 10, p2778
- ISSN
0014-2980
- Publication type
Article
- DOI
10.1002/eji.200940219