We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Listeria monocytogenes is sensed by the NLRP3 and AIM2 inflammasome.
- Authors
Kim, Sarah; Bauernfeind, Franz; Ablasser, Andrea; Hartmann, Gunther; Fitzgerald, Katherine A.; Latz, Eicke; Hornung, Veit
- Abstract
The inflammasome pathway functions to regulate caspase-1 activation in response to a broad range of stimuli. Caspase-1 activation is required for the maturation of the pivotal pro-inflammatory cytokines of the pro-IL-1β family. In addition, caspase-1 activation leads to a certain type of cell death known as pyroptosis. Activation of the inflammasome has been shown to play a critical role in the recognition and containment of various microbial pathogens, including the intracellularly replicating Listeria monocytogenes; however, the inflammasome pathways activated during L. monocytogenes infection are only poorly defined. Here, we demonstrate that L. monocytogenes activates both the NLRP3 and the AIM2 inflammasome, with a predominant involvement of the AIM2 inflammasome. In addition, L. monocytogenes-triggered cell death was diminished in the absence of both AIM2 and NLRP3, and is concomitant with increased intracellular replication of L. monocytogenes. Altogether, these data establish a role for DNA sensing through the AIM2 inflammasome in the detection of intracellularly replicating bacteria.
- Publication
European Journal of Immunology, 2010, Vol 40, Issue 6, p1545
- ISSN
0014-2980
- Publication type
Article
- DOI
10.1002/eji.201040425