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- Title
Intake of specific flavonoid classes and coronary heart disease--a case-control study in Greece.
- Authors
Lagiou, P; Samoli, E; Lagiou, A; Tzonou, A; Kalandidi, A; Peterson, J; Dwyer, J; Trichopoulos, D
- Abstract
<bold>Objective: </bold>Dietary intake of flavonoids has been reported to protect against coronary heart disease (CHD) risk, but associations of specific classes of flavonoids with CHD have not been adequately studied.<bold>Design: </bold>Hospital-based case-control study relying on interviewer administered questionnaires.<bold>Setting: </bold>Cardiology Department of the University of Athens Medical School in the Hippokrateion General Hospital (1990-1991).<bold>Subjects: </bold>Cases were 329 patients with electrocardiographically confirmed first coronary infarct or a first positive coronary arteriogram, or both (participation fraction 93%). Controls were 570 patients admitted to the same hospital for minor conditions unrelated to nutrition (participation fraction 95%). All cases and controls were interviewed in the hospital wards by experienced interviewers, and a 110-item food frequency questionnaire was administered.<bold>Results: </bold>There was statistically significant evidence (P approximately 0.03) for an inverse association between intake of flavan-3-ols and CHD risk, an increase of about 21 mg per day corresponding to a 24% decrease in CHD risk. The inverse association between flavan-3-ols and CHD risk was largely accounted for by the intake of wine and to a lesser extent tea. For none of the other flavonoid classes was there statistically significant evidence of an association.<bold>Conclusion: </bold>Flavan-3-ols, which are largely found in wine and tea, are inversely associated with, and may be protective against, coronary heart disease.
- Publication
European Journal of Clinical Nutrition, 2004, Vol 58, Issue 12, p1643
- ISSN
0954-3007
- Publication type
journal article
- DOI
10.1038/sj.ejcn.1602022