We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Mechanisms of Short-Chain Fatty Acids Derived from Gut Microbiota in Alzheimer's Disease.
- Authors
Xiao-hang Qian; Ru-yan Xie; Xiao-li Liu; Sheng-di Chen; Hui-dong Tang
- Abstract
Short-chain fatty acids (SCFAs) are important metabolites derived from the gut microbiota through fermentation of dietary fiber. SCFAs participate a number of physiological and pathological processes in the human body, such as host metabolism, immune regulation, appetite regulation. Recent studies on gut-brain interaction have shown that SCFAs are important mediators of gut-brain interactions and are involved in the occurrence and development of many neurodegenerative diseases, including Alzheimer's disease. This review summarizes the current research on the potential roles and mechanisms of SCFAs in AD. First, we introduce the metabolic distribution, specific receptors and signaling pathways of SCFAs in human body. The concentration levels of SCFAs in AD patient/animal models are then summarized. In addition, we illustrate the effects and mechanisms of SCFAs on the cognitive level, pathological features (Aβ and tau) and neuroinflammation in AD. Finally, we analyze the translational value of SCFAs as potential therapeutic targets for the treatment of AD.
- Subjects
ALZHEIMER'S disease treatment; FATTY acids; GUT microbiome
- Publication
Aging & Disease, 2022, Vol 13, Issue 4, p1252
- ISSN
2152-5250
- Publication type
Article
- DOI
10.14336/AD.2021.1215